Advance of Peripheral Nerve Injury Repair and Reconstruction

Peripheral nerve injury is a common clinical problem because the dysfunction of distal limb seriously affects patients’ quality of life, and it results in a huge social and economic burden.[1] Repair of peripheral nerve injury is a very complex pathological process. Due to slow nerve regeneration, Wallerian degeneration of nerve stump, tissue adhesion, atrophy of muscles and motor end plates and other constraints, functional rehabilitation of the damaged nerve is always restricted. The ultimate goal of repairing peripheral nerve injuries is to restore the function of the distal target organs to their original level in both sensory and motor aspect. At present, the foreign as well as the domestic researches on peripheral nerve injury mainly focus on the methods of nerve repair, promotion of axonal growth, and the functional remodeling paralleled with anatomical restoration.